Note: the conference time is Central European Summer Time (CEST)
This online event is being organized to discuss the advances in research at the interface of RNA biology and neuroscience.
We aim to bring together a panel of prominent researchers in the field to share with us their new studies and innovative approaches. We will discuss novel insights into the central nervous system and its dysfunctions at the molecular and cellular resolution.
The program consists of 5 sessions spread over two and a half days:
- Single-cell and Spatial Transcriptomics in Brain Research
- RNA Regulation in Neurons and Glia
- RNA in Brain Pathology: Neurodegeneration
- RNA in Brain Pathology: Neuro-oncology
- Nucleic Acid Therapies in the Brain
We also wish to invite early-stage career researchers to join actively and we hope to hear from you! There are 2 selected talks in each panel session and two poster sessions to be filled by you! We encourage you to apply!
9:00 - 9:10
Welcome Address from the Conference Chairs
9:10 - 10:10
Session 1 - Single-cell and Spatial Transcriptomics in Brain Research
Moderator: Monika Piwecka
10:10 - 10:45
Bożena Kamińska-Kaczmarek (Nencki Institute of Experimental Biology, PL)
Brain tumor microenvironment at single-cell resolution
10:45 - 11:10
Marek Bartosovic (Karolinska Institute, SE)
Multimodal profiling of the epigenome at single-cell resolution
11:10 - 11:45
Özgün Gökçe (Ludwig-Maximilian-University LMU, DE)
Single-cell and spatial transcriptomics characterisation of the mouse white-matter reveals adaptive immune system as driver of white matter aging
11:45 - 12:20
Agnieszka Rybak-Wolf (Berlin Institute for Medical Systems Biology, DE)
From single cells sequencing to new therapeutic approaches for Herpes Simples virus 1 driven encephalitis
12:20 - 13:00
Lunch break
13:00 – 13:20
Franz Ake (Bellvitge Institute for Biomedical Research IDIBELL, ES) – short talk
Characterization of alternative polyadenylation at single cell resolution in Alzheimer Disease
13:20 – 13:40
Ivano Legnini(Berlin Institute for Medical Systems Biology, DE) – short talk
Spatio-temporal, optogenetic control of gene expression in organoids
13:40 – 14:00
Rotem Ben Tov Perry(Weizmann Institute of Science, IL) – short talk
Roles of Silc1 lncRNA in the peripheral and central nervous system
Poster session I (Posters P.1 - P.17)
14:00 – 15:30
Viewing posters
Session 2 - RNA Regulation in Neurons and Glia
Moderator: Monika Piwecka
15:30 – 16:05
Jeroen Pasterkamp (University Medical Center Utrecht, NL)
Small and circular non-coding RNAs in neural development and neurological disease
16:05 – 16:40
Hagen Tilgner (Weill Cornell Medicine, USA)
Brain isoforms in space and time
16:40 – 17:15
Joseph Dougherty (Washington University School of Medicine, USA)
Regulation of translation in glia
17:15 – 17:30
Coffee break
17:30 – 17:50
Orna Issler (Icahn School of Medicine at Mount Sinai, USA) – short talk
A cell-type-specific role for long non-coding RNAs in depression
17:50 – 18:10
Andranik Ivanov (Berlin Institute of Health, Charité Berlin, DE) -– short talk
Circular RNA Cdr1as is dynamically regulated during the circadian rhythm and linked to light-induced phase shifts in the SCN
18:10 – 18:30
Mollie K. Meffert (The Johns Hopkins University School of Medicine, USA) – short talk
Growth regulatory miRNAs in neuroplasticity and development
Session 3 - RNA in Brain Pathology: Neurodegeneration
Moderator: Agnieszka Fiszer
10:00 – 10:35
Rickie Patani (The Francis Crick Institute, UK)
Deciphering cell type specific molecular aberrations in ALS using human stem cell models
10:35 – 11:10
Gracjan Michlewski (International Institute of Molecular and Cell Biology, PL)
RP-CONA (RNA Pull-Down Confocal NAnoscanning) detects small molecules targeting RNA-protein interactions, implicated in Parkinson’s disease
11:10 – 11:45
Evgenia Salta (Netherlands Institute for Neuroscience, NL)
Harnessing the endogenous regenerative potential to ‘rejuvenate’ the Alzheimer’s brain: from microRNAs to single-cell RNA sequencing
11:45 – 12:05
Katarzyna Tutak (Adam Mickiewicz University, PL) – short talk
Novel RAN translation modifiers of RNA harboring expanded CGG repeats in Fragile X-associated syndrome
12:05 – 12:25
Paweł Joachimiak(Institute of Bioorganic Chemistry, PL) – short talk
Precise and accurate allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models
12:25 – 12:45
Sambhavi Puri(Boston University School of Medicine, USA) – short talk
Identification of circRNAs linked to Alzheimer’s Disease and Related Dementias
12:45 – 13:30
Lunch break
Poster session II (Posters P.18 – P.33)
13:30 - 15:00
Viewing posters
Session 4 - RNA in Brain Pathology: Neuro-oncology
Moderator: Katarzyna Rolle
15:00 - 15:35
Itay Tirosh (Weizmann Institute of Science, IL)
Intra-tumor heterogeneity and cellular hierarchies in glioma
15:35 - 16:10
Agnieszka Bronisz (Mossakowski Medical Research Centre, PL)
Molecular geography of the stress response in the brain tumor glioblastoma - the lesson from transcriptome signatures
16:10 – 16:45
Anna Krichevsky (Harvard Medical School, USA)
A long road from the discovery of oncogenic non-coding RNAs in the brain to glioblastoma therapy development
16:45 – 17:05
Żaneta Zarębska(Institute of Bioorganic Chemistry, PL) – short talk
Molecular mechanism of action and clinical relevance of circCLIP2 in glioblastoma
17:05 – 17:25
Katarzyna B. Leszczyńska(Nencki Institute of Experimental Biology, PL) – short talk
Epigenetic modulation leads to the decrease of H3K27M oncohistone and transcriptomic changes in pediatric high-grade gliomas
Session 5 - Nucleic Acid Therapies in the Brain
Dedicated to the Memory of Professor Włodzimierz J. KrzyżosiakModerator: Marta Olejniczak
9:00 – 9:35
Krzysztof Sobczak (Adam Mickiewicz University, PL)
Compounds which alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats in the Fragile X–associated syndrome
9:35 – 10:10
Nicole Déglon (Lausanne University Hospital and Lausanne University, CH)
CRISPR-based approaches for the treatment of polyQ disease
10:10 – 10:45
Leontien van der Bent (uniQure biopharma B.V., NL)
Gene therapy for the treatment of CNS disorders: miQURE technology
10:45 – 11:05
Savani A. Anbalagan (Adam Mickiewicz University, PL) – short talk
Idiosyncrasy of antisense oligonucleotide targeting protein-coding gene embedded with non-coding RNA in vivo
11:05 – 11:25
Lorea Blazquez(Biodonostia Health Research Institute, ES) – short talk
Manipulation of RNA-misprocessing with CRISPR-dCas13 as a new therapeutic approach in neurodegenerative disorders
11:25 – 12:00
Closing Remarks
& Poster Awards
Sten Linnarsson
Karolinska Institute, SE
Bożena Kamińska-Kaczmarek
Nencki Institute of Experimental Biology, PL
