WEDNESDAY 28.09.2022 THURSDAY 29.09.2022 FRIDAY 30.09.2022

9:00 - 9:10

Welcome Address from the Conference Chairs

9:10 - 10:10

Keynote Lecture

Sten Linnarsson (Karolinska Institute, SE)

Cellular architecture of the human brain

Session 1 - Single-cell and Spatial Transcriptomics in Brain Research

Moderator: Monika Piwecka

10:10 - 10:45

Bożena Kamińska-Kaczmarek (Nencki Institute of Experimental Biology, PL)

Brain tumor microenvironment at single-cell resolution

10:45 - 11:10

Marek Bartosovic (Karolinska Institute, SE)

Multimodal profiling of the epigenome at single-cell resolution

11:10 - 11:45

Özgün Gökçe (Ludwig-Maximilian-University LMU, DE)

Single-cell and spatial transcriptomics characterisation of the mouse white-matter reveals adaptive immune system as driver of white matter aging

11:45 - 12:20

Agnieszka Rybak-Wolf (Berlin Institute for Medical Systems Biology, DE)

From single cells sequencing to new therapeutic approaches for Herpes Simples virus 1 driven encephalitis

12:20 - 13:00

Lunch break

13:00 – 13:20

Franz Ake (Bellvitge Institute for Biomedical Research IDIBELL, ES) – short talk

Characterization of alternative polyadenylation at single cell resolution in Alzheimer Disease

13:20 – 13:40

Ivano Legnini(Berlin Institute for Medical Systems Biology, DE) – short talk

Spatio-temporal, optogenetic control of gene expression in organoids

13:40 – 14:00

Rotem Ben Tov Perry(Weizmann Institute of Science, IL) – short talk

Roles of Silc1 lncRNA in the peripheral and central nervous system

Poster session I (Posters P.1 - P.17)

14:00 – 15:30

Viewing posters

Session 2 - RNA Regulation in Neurons and Glia

Moderator: Monika Piwecka

15:30 – 16:05

Jeroen Pasterkamp (University Medical Center Utrecht, NL)

Small and circular non-coding RNAs in neural development and neurological disease

16:05 – 16:40

Hagen Tilgner (Weill Cornell Medicine, USA)

Brain isoforms in space and time

16:40 – 17:15

17:15 – 17:30

Coffee break

17:30 – 17:50

Orna Issler (Icahn School of Medicine at Mount Sinai, USA) – short talk

A cell-type-specific role for long non-coding RNAs in depression

17:50 – 18:10

Andranik Ivanov (Berlin Institute of Health, Charité Berlin, DE) -– short talk

Circular RNA Cdr1as is dynamically regulated during the circadian rhythm and linked to light-induced phase shifts in the SCN

18:10 – 18:30

Mollie K. Meffert (The Johns Hopkins University School of Medicine, USA) – short talk

Growth regulatory miRNAs in neuroplasticity and development

Session 3 - RNA in Brain Pathology: Neurodegeneration

Moderator: Agnieszka Fiszer

10:00 – 10:35

Rickie Patani (The Francis Crick Institute, UK)

Deciphering cell type specific molecular aberrations in ALS using human stem cell models

10:35 – 11:10

Gracjan Michlewski (International Institute of Molecular and Cell Biology, PL)

RP-CONA (RNA Pull-Down Confocal NAnoscanning) detects small molecules targeting RNA-protein interactions, implicated in Parkinson’s disease

11:10 – 11:45

Evgenia Salta (Netherlands Institute for Neuroscience, NL)

Harnessing the endogenous regenerative potential to ‘rejuvenate’ the Alzheimer’s brain: from microRNAs to single-cell RNA sequencing

11:45 – 12:05

Katarzyna Tutak (Adam Mickiewicz University, PL) – short talk

Novel RAN translation modifiers of RNA harboring expanded CGG repeats in Fragile X-associated syndrome

12:05 – 12:25

Paweł Joachimiak(Institute of Bioorganic Chemistry, PL) – short talk

Precise and accurate allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models

12:25 – 12:45

Sambhavi Puri(Boston University School of Medicine, USA) – short talk

Identification of circRNAs linked to Alzheimer’s Disease and Related Dementias

12:45 – 13:30

Lunch break

Poster session II (Posters P.18 – P.33)

13:30 - 15:00

Viewing posters

Session 4 - RNA in Brain Pathology: Neuro-oncology

Moderator: Katarzyna Rolle

15:00 - 15:35

Itay Tirosh (Weizmann Institute of Science, IL)

Intra-tumor heterogeneity and cellular hierarchies in glioma

15:35 - 16:10

Agnieszka Bronisz (Mossakowski Medical Research Centre, PL)

Molecular geography of the stress response in the brain tumor glioblastoma - the lesson from transcriptome signatures

16:10 – 16:45

Anna Krichevsky (Harvard Medical School, USA)

A long road from the discovery of oncogenic non-coding RNAs in the brain to glioblastoma therapy development

16:45 – 17:05

Żaneta Zarębska(Institute of Bioorganic Chemistry, PL) – short talk

Molecular mechanism of action and clinical relevance of circCLIP2 in glioblastoma

17:05 – 17:25

Katarzyna B. Leszczyńska(Nencki Institute of Experimental Biology, PL) – short talk

Epigenetic modulation leads to the decrease of H3K27M oncohistone and transcriptomic changes in pediatric high-grade gliomas

Session 5 - Nucleic Acid Therapies in the Brain

Dedicated to the Memory of Professor Włodzimierz J. Krzyżosiak

Moderator: Marta Olejniczak

9:00 – 9:35

Krzysztof Sobczak (Adam Mickiewicz University, PL)

Compounds which alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats in the Fragile X–associated syndrome

9:35 – 10:10

Nicole Déglon (Lausanne University Hospital and Lausanne University, CH)

CRISPR-based approaches for the treatment of polyQ disease

10:10 – 10:45

Leontien van der Bent (uniQure biopharma B.V., NL)

Gene therapy for the treatment of CNS disorders: miQURE technology

10:45 – 11:05

Savani A. Anbalagan (Adam Mickiewicz University, PL) – short talk

Idiosyncrasy of antisense oligonucleotide targeting protein-coding gene embedded with non-coding RNA in vivo

11:05 – 11:25

Lorea Blazquez(Biodonostia Health Research Institute, ES) – short talk

Manipulation of RNA-misprocessing with CRISPR-dCas13 as a new therapeutic approach in neurodegenerative disorders

11:25 – 12:00

Closing Remarks
& Poster Awards

Sten Linnarsson

Karolinska Institute, SE

Bożena Kamińska-Kaczmarek

Nencki Institute of Experimental Biology, PL